age-1;asm-3

Lifespan changes: From wild type to age-1;asm-3

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Genetic mutants with age-1, asm-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    69.6

  • Lifespan change (compared to wild type)

    258.76%

  • Phenotype

    Remarkably, asm-3(ok1744);age-1(mg305) double mutants had mean lifespan 67% greater than that of age-1(mg305) single mutants, or 259% greater than that of wild-type animals 

  • Lifespan comparisons

    Double mutant age-1(mg305);asm-3(ok1744) has a lifespan of 69.6 days, while single mutant age-1(mg305) has a lifespan of 41.7 days, single mutant asm-3(ok1744) has a lifespan of 21.2 days and wild type has a lifespan of 19.4 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Kim Y, Sun H, 2012;7(9):e45890., ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. PLoS One. 7(9):e45890 PubMed 23049887 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 asm-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein


Locus: CELE_B0334.8


Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase


Locus: CELE_W03G1.7


Wormbase description: none available


Orthologs of age-1;asm-3 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
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Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of asm-3 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group