aakg-4;rsks-1

Lifespan changes: From wild type to aakg-4;rsks-1 / From aakg-4;rsks-1 to multiple mutants

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Genetic mutants with aakg-4, rsks-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Lifespan (days)

    15.0

  • Lifespan change (compared to wild type)

    10.29%

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);rsks-1(ok1255) has a lifespan of 15.0 days, while single mutant rsks-1(ok1255) has a lifespan of 15.2 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 13.6 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Lifespan (days)

    13.2

  • Lifespan change (compared to wild type)

    3.12%

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);rsks-1(ok1255) has a lifespan of 13.2 days, while single mutant rsks-1(ok1255) has a lifespan of 14.5 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 12.8 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakg-4 rsks-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit


Locus: CELE_T01B6.3


Wormbase description: aakg-4 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Ribosomal protein S6 kinase beta


Locus: CELE_Y47D3A.16


Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).


Orthologs of aakg-4;rsks-1 in SynergyAge
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Orthologs of aakg-4 in SynergyAge
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Species Gene
Orthologs of rsks-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
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