aakg-4;daf-2;rsks-1

Lifespan changes: From wild type to aakg-4;daf-2;rsks-1

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with aakg-4, daf-2, rsks-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Lifespan (days)

    26.0

  • Lifespan change (compared to wild type)

    91.18%

  • Phenotype

    aakg-4, which encodes the gamma regulatory subunit of AMPK, showed the strongest suppression of daf-2 rsks-1 upon inhibition

  • Lifespan comparisons

    Triple mutant aakg-4(RNAi);daf-2(e1370);rsks-1(ok1255) has a lifespan of 26.0 days, while double mutant daf-2(e1370);rsks-1(ok1255) has a lifespan of 50.5 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 13.6 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Lifespan (days)

    24.4

  • Lifespan change (compared to wild type)

    90.63%

  • Phenotype

    aakg-4, which encodes the gamma regulatory subunit of AMPK, showed the strongest suppression of daf-2 rsks-1 upon inhibition

  • Lifespan comparisons

    Triple mutant aakg-4(RNAi);daf-2(e1370);rsks-1(ok1255) has a lifespan of 24.4 days, while double mutant daf-2(e1370);rsks-1(ok1255) has a lifespan of 50.0 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 12.8 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakg-4 daf-2 rsks-1 aakg-4;daf-2;rsks-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit


Locus: CELE_T01B6.3


Wormbase description: aakg-4 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Ribosomal protein S6 kinase beta


Locus: CELE_Y47D3A.16


Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).


Orthologs of aakg-4;daf-2;rsks-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of aakg-4 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of daf-2 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster InR
Orthologs of rsks-1 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group