Pink1;Snca

Lifespan changes: From wild type to Pink1;Snca

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Genetic mutants with Pink1, Snca alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Diet

    ad libitum

  • Lifespan (days)

    546.0

  • Lifespan change (compared to wild type)

    0.18%

  • Lifespan comparisons

    Double mutant Pink1(KO);Snca(KO) has a lifespan of 546.0 days, while wild type has a lifespan of 723.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Gispert S et al., 2015, Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet. 24(4):1061-76 PubMed 25296918 Click here to select all mutants from this PubMed ID in the graph

Search genes: Pink1 Snca
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

PTEN induced putative kinase 1


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

synuclein, alpha


Orthologs of Pink1;Snca in SynergyAge
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Species Gene
Orthologs of Pink1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Snca in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group