Kl;Pai1

Lifespan changes: From wild type to Kl;Pai1

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Genetic mutants with Kl, Pai1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Diet

    ad libitum, standard rodent chow diet

  • Lifespan (days)

    163.0

  • Lifespan comparisons

    Double mutant kl(KO);pai-1(KO) has a lifespan of 163.0 days, while single mutant kl(KO) has a lifespan of 58.0 days.

  • Citation
    View abstract

    Eren M et al., 2014, PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 111(19):7090-5 PubMed 24778222 Click here to select all mutants from this PubMed ID in the graph

  • Diet

    ad libitum, standard rodent chow diet

  • Lifespan (days)

    246.0

  • Lifespan comparisons

    Double mutant kl(KO);pai-1(KO) has a lifespan of 246.0 days, while single mutant kl(KO) has a lifespan of 58.0 days.

  • Citation
    View abstract

    Eren M et al., 2014, PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 111(19):7090-5 PubMed 24778222 Click here to select all mutants from this PubMed ID in the graph

Search genes: Kl Pai1
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

klotho


  • Symbol
  • GenAge

No gene information for Pai1


Orthologs of Kl;Pai1 in SynergyAge
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Orthologs of Kl in SynergyAge
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Orthologs of Pai1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

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