Ku80;Prkdc

Lifespan changes: From wild type to Ku80;Prkdc

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Genetic mutants with Ku80, Prkdc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    ad libitum

  • Lifespan (days)

    243.6

  • Phenotype

    The dna-pk mice live significantly longer compared to ku80-/- mice in both male (p = 0.01) and females (p = 8.7*10-6) mice.Survival of double knock out mice is identical to ku80-/-

  • Lifespan comparisons

    Double mutant dna-pk(CS);ku80(KO) has a lifespan of 243.6 days, while single mutant dna-pk(CS) has a lifespan of 296.8 days and single mutant ku80(KO) has a lifespan of 238.0 days.

  • Citation
    View abstract

    Reiling E et al., 2014, The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency. PLoS One. 9(4):e93568 PubMed 24740260 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    ad libitum

  • Lifespan (days)

    230.3

  • Phenotype

    The dna-pk mice live significantly longer compared to ku80-/- mice in both male (p = 0.01) and females (p = 8.7*10-6) mice.Survival of double knock out mice is identical to ku80-/-

  • Lifespan comparisons

    Double mutant dna-pk(CS);ku80(KO) has a lifespan of 230.3 days, while single mutant dna-pk(CS) has a lifespan of 276.5 days and single mutant ku80(KO) has a lifespan of 226.8 days.

  • Citation
    View abstract

    Reiling E et al., 2014, The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency. PLoS One. 9(4):e93568 PubMed 24740260 Click here to select all mutants from this PubMed ID in the graph

Search genes: Ku80 Prkdc
  • Symbol
  • GenAge

No gene information for Ku80


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

protein kinase, DNA activated, catalytic polypeptide


Orthologs of Ku80;Prkdc in SynergyAge
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Species Gene
Orthologs of Ku80 in SynergyAge
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Species Gene
Orthologs of Prkdc in SynergyAge
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Species Gene
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

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