Ku70;Ku80

Lifespan changes: From wild type to Ku70;Ku80

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Genetic mutants with Ku70, Ku80 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    259.0

  • Lifespan change (compared to wild type)

    -65.74%

  • Phenotype

    Homozygous and heterozygous knock out of Ku70, Ku80, or both results in identical premature aging phenotypes without substantially increasing the incidence of cancer.

  • Lifespan comparisons

    Double mutant Ku70(KO);Ku80(KO) has a lifespan of 259.0 days, while single mutant Ku80(KO) has a lifespan of 259.0 days, single mutant Ku70(KO) has a lifespan of 259.0 days and wild type has a lifespan of 756.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Li H et al., 2007, Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol. 27(23):8205-14 PubMed 17875923 Click here to select all mutants from this PubMed ID in the graph

Search genes: Ku70 Ku80
  • Symbol
  • GenAge

No gene information for Ku70


  • Symbol
  • GenAge

No gene information for Ku80


Orthologs of Ku70;Ku80 in SynergyAge
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Species Gene
Orthologs of Ku70 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Ku80 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group