Apc;Ku80

Lifespan changes: From wild type to Apc;Ku80

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Genetic mutants with Apc, Ku80 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    23

  • Diet

    Standard lab chow (Harlan Teklad, Madison WI) and water were supplied ad libitum

  • Lifespan (days)

    294.0

  • Lifespan change (compared to wild type)

    -66.40%

  • Phenotype

    The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 homozygous -/- mutants has decreased lifespan compared to WT and single mutants

  • Lifespan comparisons

    Double mutant Apc(MIN);Ku80(KO) has a lifespan of 294.0 days, while single mutant Ku80(KO) has a lifespan of 504.0 days, single mutant Apc(MIN) has a lifespan of 280.0 days and wild type has a lifespan of 875.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Holcomb VB et al., 2008, Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 68(22):9497-502 PubMed 19010925 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    23

  • Diet

    Standard lab chow (Harlan Teklad, Madison WI) and water were supplied ad libitum

  • Lifespan (days)

    231.0

  • Lifespan change (compared to wild type)

    -73.60%

  • Phenotype

    The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 heterozygous +/- mutants has decreased lifespan compared to WT and single mutants

  • Lifespan comparisons

    Double mutant Apc(MIN);Ku80(KO) has a lifespan of 231.0 days, while single mutant Ku80(KO) has a lifespan of 791.0 days, single mutant Apc(MIN) has a lifespan of 280.0 days and wild type has a lifespan of 875.0 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Holcomb VB et al., 2008, Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 68(22):9497-502 PubMed 19010925 Click here to select all mutants from this PubMed ID in the graph

Search genes: Apc Ku80
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

adenomatosis polyposis coli


  • Symbol
  • GenAge

No gene information for Ku80


Orthologs of Apc;Ku80 in SynergyAge
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Species Gene
Orthologs of Apc in SynergyAge
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Species Gene
Orthologs of Ku80 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group