p27;Trp53

Lifespan changes: From wild type to p27;Trp53

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with p27, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    114.0

  • Phenotype

    Double p27/p53 mutant lives much less compared to the single mutant p27, as well as compared to the p53 single mutant

  • Lifespan comparisons

    Double mutant p27(KO);p53(KO) has a lifespan of 114.0 days, while single mutant p53(KO) has a lifespan of 145.0 days and single mutant p27(KO) has a lifespan of 259.0 days.

  • Citation
    View abstract

    Damo LA et al., 2005, Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. Mol Carcinog. 42(2):109-20 PubMed 15584024 Click here to select all mutants from this PubMed ID in the graph

Search genes: p27 Trp53
  • Symbol
  • GenAge

No gene information for p27


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53


Orthologs of p27;Trp53 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of p27 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group