Sirt6;Trp53

Lifespan changes: From wild type to Sirt6;Trp53

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Genetic mutants with Sirt6, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    344.0

  • Lifespan change (compared to wild type)

    -67.61%

  • Phenotype

    Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) female mice.

  • Lifespan comparisons

    Double mutant Sirt6(KO);p53(KO) has a lifespan of 344.0 days, while single mutant Sirt6(KO) has a lifespan of 24.0 days, single mutant p53(KO) has a lifespan of 473.0 days and wild type has a lifespan of 1062.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Ghosh S et al., 2018, Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. Elife. 7. pii: e32127 PubMed 29474172 Click here to select all mutants from this PubMed ID in the graph

  • Lifespan (days)

    237.0

  • Lifespan change (compared to wild type)

    -76.32%

  • Phenotype

    Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) male mice.

  • Lifespan comparisons

    Double mutant Sirt6(KO);p53(KO) has a lifespan of 237.0 days, while single mutant Sirt6(KO) has a lifespan of 24.0 days, single mutant p53(KO) has a lifespan of 473.0 days and wild type has a lifespan of 1001.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Ghosh S et al., 2018, Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. Elife. 7. pii: e32127 PubMed 29474172 Click here to select all mutants from this PubMed ID in the graph

Search genes: Sirt6 Trp53
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

sirtuin 6


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53


Orthologs of Sirt6;Trp53 in SynergyAge
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Species Gene
Orthologs of Sirt6 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group