abu-11;daf-2

Lifespan changes: From wild type to abu-11;daf-2

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Genetic mutants with abu-11, daf-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    28.6

  • Lifespan change (compared to wild type)

    40.20%

  • Phenotype

    Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type.

  • Lifespan comparisons

    Double mutant abu-11(RNAi);daf-2(e1368) has a lifespan of 28.6 days, while single mutant abu-11(RNAi) has a lifespan of 16.4 days, single mutant daf-2(e1368) has a lifespan of 32.3 days and wild type has a lifespan of 20.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Henis-Korenblit S et al., 2010, Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 107(21):9730-5 PubMed 20460307 Click here to select all mutants from this PubMed ID in the graph

  • Lifespan (days)

    31.9

  • Lifespan change (compared to wild type)

    61.11%

  • Phenotype

    Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type.

  • Lifespan comparisons

    Double mutant abu-11(RNAi);daf-2(e1368) has a lifespan of 31.9 days, while single mutant abu-11(RNAi) has a lifespan of 18.1 days, single mutant daf-2(e1368) has a lifespan of 31.5 days and wild type has a lifespan of 19.8 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Henis-Korenblit S et al., 2010, Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 107(21):9730-5 PubMed 20460307 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    45.5

  • Lifespan change (compared to wild type)

    123.04%

  • Phenotype

    Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type.

  • Lifespan comparisons

    Double mutant abu-11(RNAi);daf-2(e1370) has a lifespan of 45.5 days, while single mutant abu-11(RNAi) has a lifespan of 16.4 days, single mutant daf-2(e1370) has a lifespan of 44.6 days and wild type has a lifespan of 20.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Henis-Korenblit S et al., 2010, Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 107(21):9730-5 PubMed 20460307 Click here to select all mutants from this PubMed ID in the graph

  • Lifespan (days)

    41.0

  • Lifespan change (compared to wild type)

    107.07%

  • Phenotype

    Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type.

  • Lifespan comparisons

    Double mutant abu-11(RNAi);daf-2(e1370) has a lifespan of 41.0 days, while single mutant abu-11(RNAi) has a lifespan of 18.1 days, single mutant daf-2(e1370) has a lifespan of 46.0 days and wild type has a lifespan of 19.8 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Henis-Korenblit S et al., 2010, Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 107(21):9730-5 PubMed 20460307 Click here to select all mutants from this PubMed ID in the graph

Search genes: abu-11 daf-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Activated in Blocked Unfolded protein response


Locus: CELE_T01D1.6


Wormbase description: abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


Orthologs of abu-11;daf-2 in SynergyAge
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Species Gene
Orthologs of abu-11 in SynergyAge
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Species Gene
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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