HDAC1;Sirt1

Lifespan changes: From wild type to HDAC1;Sirt1 DF = decrease in function; IF = increase in function

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Genetic mutants with HDAC1, Sirt1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    rpd3[def24];dSir[17]

  • Temperature °C

    25

  • Diet

    high-calorie (15% yeast, 15% sucrose, and 2% agar)

  • Lifespan (days)

    66.0

  • Phenotype

    Flies with both a dSir2 mutation and rpd3 (def24) mutation were not long-lived, whereas their counterparts, flies mutant for only rpd3(def24), remained long-livedr2 and Rpd3, therefore, seem to be in the calorie-reduction life-span-extending pathway in flies.

  • Lifespan comparisons

    Double mutant dSir2(IF);rpd3(IF) has a lifespan of 66.0 days, while single mutant dSir2(IF) has a lifespan of 68.0 days and single mutant rpd3(IF) has a lifespan of 85.0 days.

  • Citation
    View abstract

    Rogina B, Helfand SL, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 101(45):15998-6003 PubMed 15520384 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    rpd3[def24];dSir2[EP2300]

  • Temperature °C

    25

  • Diet

    high-calorie (15% yeast, 15% sucrose, and 2% agar)

  • Lifespan (days)

    48.0

  • Lifespan change (compared to wild type)

    -5.88%

  • Lifespan comparisons

    Double mutant dSir2(IF);rpd3(IF) has a lifespan of 48.0 days, while single mutant rpd3(IF) has a lifespan of 59.0 days and wild type has a lifespan of 51.0 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Rogina B, Helfand SL, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 101(45):15998-6003 PubMed 15520384 Click here to select all mutants from this PubMed ID in the graph

Search genes: HDAC1 Sirt1
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Histone deacetylase 1


Locus: Dmel_CG7471


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Sirtuin 1


Locus: Dmel_CG5216


Orthologs of HDAC1;Sirt1 in SynergyAge
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Species Gene
Orthologs of HDAC1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Sirt1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group