alpha-Man-Ia;Edem1

Lifespan changes: From wild type to alpha-Man-Ia;Edem1 DF = decrease in function; IF = increase in function

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Genetic mutants with alpha-Man-Ia, Edem1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    P{EP}p1130[EP1130];P{EP}Edem1[EP1588]

  • Temperature °C

    25

  • Diet

    standard food

  • Lifespan (days)

    58.0

  • Lifespan change (compared to wild type)

    31.82%

  • Phenotype

    The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.

  • Lifespan comparisons

    Double mutant edem1(DF);mas-1(DF) has a lifespan of 58.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 65.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 PubMed 19302370 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    alpha-Man-la[EP1628];P{EP}Edem1[EP1588]

  • Temperature °C

    25

  • Diet

    standard food

  • Lifespan (days)

    62.0

  • Lifespan change (compared to wild type)

    40.91%

  • Phenotype

    The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.

  • Lifespan comparisons

    Double mutant edem1(DF);mas-1(DF) has a lifespan of 62.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 57.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Almost additive (positive)

  • Citation
    View abstract

    Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 PubMed 19302370 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    alpha-Man-la[EP982];P{EP}Edem1[EP1588]

  • Temperature °C

    25

  • Diet

    standard food

  • Lifespan (days)

    60.0

  • Lifespan change (compared to wild type)

    36.36%

  • Phenotype

    The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.

  • Lifespan comparisons

    Double mutant edem1(DF);mas-1(DF) has a lifespan of 60.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 57.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Almost additive (positive)

  • Citation
    View abstract

    Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 PubMed 19302370 Click here to select all mutants from this PubMed ID in the graph

Search genes: alpha-Man-Ia Edem1
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

alpha-Mannosidase class I a


Locus: Dmel_CG42275


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

ER degradation enhancer, mannosidase alpha-like 1


Locus: Dmel_CG3810


Orthologs of alpha-Man-Ia;Edem1 in SynergyAge
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Orthologs of alpha-Man-Ia in SynergyAge
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Species Gene
Orthologs of Edem1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group