dhd;Trx-2

Lifespan changes: From wild type to dhd;Trx-2 DF = decrease in function; IF = increase in function

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Genetic mutants with dhd, Trx-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    Trx-2[6];dhd[J5]

  • Temperature °C

    25

  • Lifespan (days)

    51.5

  • Lifespan change (compared to wild type)

    -4.10%

  • Phenotype

    The dhd- mutant (w Df(1)J5) had very similar lifespans to the control and the double mutant had only a slightly shorter lifespan than the single dhd- mutant.

  • Lifespan comparisons

    Double mutant Trx-2(DF);dhd(DF) has a lifespan of 51.5 days, while single mutant dhd(DF) has a lifespan of 53.0 days, single mutant Trx-2(DF) has a lifespan of 53.5 days and wild type has a lifespan of 53.7 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Svensson MJ, Larsson J, 2007, Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Hereditas. 144(1):25-32 PubMed 17567437 Click here to select all mutants from this PubMed ID in the graph

Search genes: dhd Trx-2
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

deadhead


Locus: Dmel_CG4193


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

thioredoxin-2


Locus: Dmel_CG31884


Orthologs of dhd;Trx-2 in SynergyAge
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Species Gene
Orthologs of dhd in SynergyAge
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Species Gene
Orthologs of Trx-2 in SynergyAge
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Species Gene
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
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