foxo;InR

Lifespan changes: From wild type to foxo;InR DF = decrease in function; IF = increase in function

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Genetic mutants with foxo, InR alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    foxo[delta94];P{UAS-InR.DN.U}

  • Temperature °C

    25

  • Diet

    sugar/yeast medium

  • Lifespan (days)

    53.0

  • Lifespan change (compared to wild type)

    -13.11%

  • Phenotype

    Overexpression of a dominant negative form of the Drosophila insulin receptor (UAS-InRDN) under the control of the ubiquitous and constitutive daughterless-GAL4 driver (daGAL) results in females having a significantly longer median lifespan than controls. The same effect is however strongly attenuated in a dFoxo background and negative control of InR si very weak, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%.

  • Lifespan comparisons

    Double mutant foxo(DF);inR(DF) has a lifespan of 53.0 days, while single mutant inR(DF) has a lifespan of 71.0 days, single mutant foxo(DF) has a lifespan of 49.0 days and wild type has a lifespan of 61.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    foxo[delta94];P{UAS-InR.DN.U}

  • Temperature °C

    25

  • Diet

    sugar/yeast medium

  • Lifespan (days)

    46.0

  • Lifespan change (compared to wild type)

    -31.34%

  • Phenotype

    Adult-conditioned expression of a dominant negative form of insulin receptor (UAS-InRDN) under the control of the inducible daughterless-GeneSwitch (daGS) driver, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%.

  • Lifespan comparisons

    Double mutant foxo(DF);inR(DF) has a lifespan of 46.0 days, while single mutant inR(DF) has a lifespan of 83.0 days, single mutant foxo(DF) has a lifespan of 44.0 days and wild type has a lifespan of 67.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

Search genes: foxo InR
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

forkhead box, sub-group O


Locus: Dmel_CG3143


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Insulin-like receptor


Locus: Dmel_CG18402


Orthologs of foxo;InR in SynergyAge
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Species Gene
Orthologs of foxo in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of InR in SynergyAge
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Species Gene
Caenorhabditis elegans daf-2
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group