Cat;Sod1

Lifespan changes: From wild type to Cat;Sod1 DF = decrease in function; IF = increase in function

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Genetic mutants with Cat, Sod1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    CAT[2A2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    51.24

  • Lifespan change (compared to wild type)

    8.19%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 51.24 days, while single mutant Sod1(IF) has a lifespan of 60.53 days, single mutant Cat(IF) has a lifespan of 42.86 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    52.11

  • Lifespan change (compared to wild type)

    10.03%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 52.11 days, while single mutant Sod1(IF) has a lifespan of 60.53 days, single mutant Cat(IF) has a lifespan of 60.91 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    42.71

  • Lifespan change (compared to wild type)

    -9.82%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 42.71 days, while single mutant Sod1(IF) has a lifespan of 60.53 days, single mutant Cat(IF) has a lifespan of 44.1 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    43.28

  • Lifespan change (compared to wild type)

    -8.61%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 43.28 days, while single mutant Sod1(IF) has a lifespan of 57.38 days, single mutant Cat(IF) has a lifespan of 42.86 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    49.5

  • Lifespan change (compared to wild type)

    4.52%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 49.5 days, while single mutant Sod1(IF) has a lifespan of 57.38 days, single mutant Cat(IF) has a lifespan of 60.91 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    57.86

  • Lifespan change (compared to wild type)

    22.17%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 57.86 days, while single mutant Sod1(IF) has a lifespan of 57.38 days, single mutant Cat(IF) has a lifespan of 44.1 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    36.27

  • Lifespan change (compared to wild type)

    -23.42%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 36.27 days, while single mutant Sod1(IF) has a lifespan of 39.71 days, single mutant Cat(IF) has a lifespan of 30.88 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    37.22

  • Lifespan change (compared to wild type)

    -21.41%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 37.22 days, while single mutant Sod1(IF) has a lifespan of 39.71 days, single mutant Cat(IF) has a lifespan of 36.43 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    33.5

  • Lifespan change (compared to wild type)

    -29.27%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 33.5 days, while single mutant Sod1(IF) has a lifespan of 39.71 days, single mutant Cat(IF) has a lifespan of 27.68 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    29.8

  • Lifespan change (compared to wild type)

    -37.08%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 29.8 days, while single mutant Sod1(IF) has a lifespan of 34.54 days, single mutant Cat(IF) has a lifespan of 30.88 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    36.93

  • Lifespan change (compared to wild type)

    -22.02%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 36.93 days, while single mutant Sod1(IF) has a lifespan of 34.54 days, single mutant Cat(IF) has a lifespan of 36.43 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SDO[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    38.9

  • Lifespan change (compared to wild type)

    -17.86%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 38.9 days, while single mutant Sod1(IF) has a lifespan of 34.54 days, single mutant Cat(IF) has a lifespan of 27.68 days and wild type has a lifespan of 47.36 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    47.84

  • Lifespan change (compared to wild type)

    4.50%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 47.84 days, while single mutant Sod1(IF) has a lifespan of 62.56 days, single mutant Cat(IF) has a lifespan of 40.62 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    50.41

  • Lifespan change (compared to wild type)

    10.11%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 50.41 days, while single mutant Sod1(IF) has a lifespan of 62.56 days, single mutant Cat(IF) has a lifespan of 61.97 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    56.8

  • Lifespan change (compared to wild type)

    24.07%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 56.8 days, while single mutant Sod1(IF) has a lifespan of 62.56 days, single mutant Cat(IF) has a lifespan of 42.51 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    40.99

  • Lifespan change (compared to wild type)

    -10.46%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 40.99 days, while single mutant Sod1(IF) has a lifespan of 53.09 days, single mutant Cat(IF) has a lifespan of 40.62 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    51.16

  • Lifespan change (compared to wild type)

    11.75%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 51.16 days, while single mutant Sod1(IF) has a lifespan of 53.09 days, single mutant Cat(IF) has a lifespan of 61.97 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    59.07

  • Lifespan change (compared to wild type)

    29.03%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and an increase in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 59.07 days, while single mutant Sod1(IF) has a lifespan of 53.09 days, single mutant Cat(IF) has a lifespan of 42.51 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    36.63

  • Lifespan change (compared to wild type)

    -19.99%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 36.63 days, while single mutant Sod1(IF) has a lifespan of 39.5 days, single mutant Cat(IF) has a lifespan of 34.17 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    37.33

  • Lifespan change (compared to wild type)

    -18.46%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 37.33 days, while single mutant Sod1(IF) has a lifespan of 39.5 days, single mutant Cat(IF) has a lifespan of 39.28 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3A1]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    38.55

  • Lifespan change (compared to wild type)

    -15.79%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 38.55 days, while single mutant Sod1(IF) has a lifespan of 39.5 days, single mutant Cat(IF) has a lifespan of 31.26 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2A2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    30.09

  • Lifespan change (compared to wild type)

    -34.27%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 30.09 days, while single mutant Sod1(IF) has a lifespan of 38.93 days, single mutant Cat(IF) has a lifespan of 34.17 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B2];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    39.84

  • Lifespan change (compared to wild type)

    -12.98%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 39.84 days, while single mutant Sod1(IF) has a lifespan of 38.93 days, single mutant Cat(IF) has a lifespan of 39.28 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    CAT[2B12];SOD[3B2]

  • Temperature °C

    25

  • Diet

    cornmeal-agar medium

  • Lifespan (days)

    46.68

  • Lifespan change (compared to wild type)

    1.97%

  • Phenotype

    Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and an increase in lifespan compared to the Sod1 single mutant.

  • Lifespan comparisons

    Double mutant Cat(IF);Sod1(IF) has a lifespan of 46.68 days, while single mutant Sod1(IF) has a lifespan of 38.93 days, single mutant Cat(IF) has a lifespan of 31.26 days and wild type has a lifespan of 45.78 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Sun J, Tower J, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 19(1):216-28 PubMed 9858546 Click here to select all mutants from this PubMed ID in the graph

Search genes: Cat Sod1
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Catalase


Locus: Dmel_CG6871


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Superoxide dismutase 1


Locus: Dmel_CG11793


Orthologs of Cat;Sod1 in SynergyAge
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Species Gene
Orthologs of Cat in SynergyAge
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Species Gene
Orthologs of Sod1 in SynergyAge
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Species Gene
Caenorhabditis elegans sod-1
Caenorhabditis elegans sod-5
Mus musculus Sod1
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group