Nf1;Nf1

Lifespan changes: From wild type to Nf1;Nf1 DF = decrease in function; IF = increase in function

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Genetic mutants with Nf1, Nf1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    NF1[P1];NF1[P2];

  • Temperature °C

    25

  • Diet

    cornmeal agar medium

  • Lifespan (days)

    34.0

  • Lifespan change (compared to wild type)

    -22.73%

  • Phenotype

    Inactivation of the NF1 gene reduced life spans in females. NF1 mutant strains (NF1 and NF1 ) and their intercross (NF1 p1/p2) showed shorter life spans than the control K33.

  • Lifespan comparisons

    Double mutant Nf1(DF);Nf1(DF) has a lifespan of 34.0 days, while single mutant Nf1(DF) has a lifespan of 34.0 days, single mutant Nf1(DF) has a lifespan of 12.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 PubMed 17369827 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    NF1[P1];NF1[P2];

  • Temperature °C

    25

  • Diet

    cornmeal agar medium

  • Lifespan (days)

    38.0

  • Lifespan change (compared to wild type)

    -24.00%

  • Phenotype

    The NF1 P1 mutant strain had a 60%-73% reduction in life span, and the NF1 P2 mutant strain had a 24%-40% reduction in life span, relative to the isogenic K33 control strain. The NF1 P1/P2 intercross heterozygotes had a life span similar to the NF1 P2 flies.

  • Lifespan comparisons

    Double mutant Nf1(DF);Nf1(DF) has a lifespan of 38.0 days, while single mutant Nf1(DF) has a lifespan of 38.0 days, single mutant Nf1(DF) has a lifespan of 20.0 days and wild type has a lifespan of 50.0 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 PubMed 17369827 Click here to select all mutants from this PubMed ID in the graph

Search genes: Nf1 Nf1
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Neurofibromin 1


Locus: Dmel_CG8318


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Neurofibromin 1


Locus: Dmel_CG8318


Orthologs of Nf1;Nf1 in SynergyAge
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Species Gene
Orthologs of Nf1 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group