Nf1;rut

Lifespan changes: From wild type to Nf1;rut DF = decrease in function; IF = increase in function

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Genetic mutants with Nf1, rut alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    rut[1];NF1[P2]

  • Temperature °C

    25

  • Diet

    cornmeal agar medium

  • Lifespan (days)

    19.0

  • Lifespan change (compared to wild type)

    -56.82%

  • Phenotype

    Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity.

  • Lifespan comparisons

    Double mutant Nf1(DF);rut(DF) has a lifespan of 19.0 days, while single mutant rut(DF) has a lifespan of 33.0 days, single mutant Nf1(DF) has a lifespan of 34.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 PubMed 17369827 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    rut[1];NF1[P2]

  • Temperature °C

    25

  • Diet

    cornmeal agar medium

  • Lifespan (days)

    25.0

  • Lifespan change (compared to wild type)

    -50.00%

  • Phenotype

    Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity.

  • Lifespan comparisons

    Double mutant Nf1(DF);rut(DF) has a lifespan of 25.0 days, while single mutant rut(DF) has a lifespan of 20.0 days, single mutant Nf1(DF) has a lifespan of 38.0 days and wild type has a lifespan of 50.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 PubMed 17369827 Click here to select all mutants from this PubMed ID in the graph

Search genes: Nf1 rut
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Neurofibromin 1


Locus: Dmel_CG8318


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

rutabaga


Locus: Dmel_CG9533


Orthologs of Nf1;rut in SynergyAge
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Species Gene
Orthologs of Nf1 in SynergyAge
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Species Gene
Orthologs of rut in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group