acdh-13;daf-16;rrf-3

Lifespan changes: From wild type to acdh-13;daf-16;rrf-3

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with acdh-13, daf-16, rrf-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    13.16

  • Lifespan change (compared to wild type)

    12.19%

  • Lifespan comparisons

    Triple mutant acdh-13(RNAi);daf-16(mgDf47);rrf-3(pk1426) has a lifespan of 13.16 days, while single mutant acdh-13(RNAi) has a lifespan of 18.4 days, double mutant daf-16(mgDf47);rrf-3(pk1426) has a lifespan of 10.25 days and wild type has a lifespan of 11.73 days.

  • Citation
    View abstract

    Kim Y, Sun H, 2007, Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. Aging Cell. 6(4):489-503 PubMed 17608836 Click here to select all mutants from this PubMed ID in the graph

Search genes: acdh-13 daf-16 rrf-3 acdh-13;daf-16;rrf-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Acyl CoA DeHydrogenase


Locus: CELE_C28C12.9


Wormbase description: gei-9 encodes a protein containing a putative acyl-CoA dehydrogenase domain; interacts with GEX-3 in yeast two-hybrid assays.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Forkhead box protein O;hypothetical protein


Locus: CELE_R13H8.1


Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RNA-dependent RNA polymerase Family


Locus: CELE_F10B5.7


Wormbase description: rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.


Orthologs of acdh-13;daf-16;rrf-3 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of acdh-13 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of daf-16 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of rrf-3 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group