aak-2;let-711

Lifespan changes: From wild type to aak-2;let-711

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Genetic mutants with aak-2, let-711 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    17.3

  • Lifespan change (compared to wild type)

    -14.78%

  • Lifespan comparisons

    Double mutant aak-2(ok524);let-711(RNAi) has a lifespan of 17.3 days, while single mutant let-711(RNAi) has a lifespan of 19.0 days, single mutant aak-2(ok524) has a lifespan of 17.1 days and wild type has a lifespan of 20.3 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Rogers AN et al., 2011, Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 14(1):55-66 PubMed 21723504 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 let-711
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

hypothetical protein


Locus: CELE_F57B9.2


Wormbase description: let-711 encodes the C. elegans ortholog of NOT1, the conserved core component of the multisubunit CCR4/NOT complex that plays a role in regulation of gene expression via various processes including transcriptional control, mRNA deadenylation, and protein ubiquitination; in C. elegans, let-711 activity is essential for embryonic and larval development and in particular, for proper spindle positioning, microtubule length, and centrosome morphology in early embryos; in addition, let-711 is essential for normal germline development and levels of fertility; in embryos, let-711 mutations can suppress the short microtubule phenotype produced by mutations in zyg-9, which encodes the C. elegans XMAP125 homolog, and centrosomoal ZYG-9 levels are increased in let-711 mutants, suggesting that let-711 functions, in part, by negatively regulating ZYG-9 levels or localization; in situ hybridization studies indicate that let-711 mRNA is broadly expressed in the gonad and that its gonadal expression is negatively regulated by lin-35/Rb.


Orthologs of aak-2;let-711 in SynergyAge
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Species Gene
Orthologs of aak-2 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of let-711 in SynergyAge
Show in SynergyAge
Species Gene
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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