aak-2;nmur-1

Lifespan changes: From wild type to aak-2;nmur-1

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Genetic mutants with aak-2, nmur-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    OP50

  • Lifespan (days)

    13.8

  • Lifespan change (compared to wild type)

    23.21%

  • Phenotype

    We found that loss of nmur-1 can still extend the lifespan of animals with a mutation in the AMP-dependent kinase aak-2, which regulatesenergy metabolism.

  • Lifespan comparisons

    Double mutant aak-2(ok524);nmur-1(ok1387) has a lifespan of 13.8 days, while single mutant nmur-1(ok1387) has a lifespan of 14.8 days, single mutant aak-2(ok524) has a lifespan of 10.8 days and wild type has a lifespan of 11.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 PubMed 20520844 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 nmur-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NMUR (NeuroMedin U Receptor) homolog


Locus: CELE_C48C5.1


Wormbase description: none available


Orthologs of aak-2;nmur-1 in SynergyAge
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Species Gene
Orthologs of aak-2 in SynergyAge
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Species Gene
Orthologs of nmur-1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group