aak-2;frh-1

Lifespan changes: From wild type to aak-2;frh-1 / From aak-2;frh-1 to multiple mutants

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Genetic mutants with aak-2, frh-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    23.1

  • Lifespan change (compared to wild type)

    34.30%

  • Phenotype

    The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi.

  • Lifespan comparisons

    Double mutant aak-2(ok524);frh-1(RNAi) has a lifespan of 23.1 days, while single mutant frh-1(RNAi) has a lifespan of 20.6 days, single mutant aak-2(ok524) has a lifespan of 17.9 days and wild type has a lifespan of 17.2 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    16.3

  • Lifespan change (compared to wild type)

    -5.23%

  • Phenotype

    The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi.

  • Lifespan comparisons

    Double mutant aak-2(rr48);frh-1(RNAi) has a lifespan of 16.3 days, while single mutant frh-1(RNAi) has a lifespan of 20.6 days, single mutant aak-2(rr48) has a lifespan of 12.6 days and wild type has a lifespan of 17.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 frh-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Frataxin, mitochondrial


Locus: CELE_F59G1.7


Wormbase description: frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.


Orthologs of aak-2;frh-1 in SynergyAge
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Orthologs of aak-2 in SynergyAge
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Orthologs of frh-1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group