aak-1;aak-2;frh-1

Lifespan changes: From wild type to aak-1;aak-2;frh-1

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Genetic mutants with aak-1, aak-2, frh-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    17.9

  • Lifespan change (compared to wild type)

    4.07%

  • Lifespan comparisons

    Triple mutant aak-1(tm1994);aak-2(ok524);frh-1(RNAi) has a lifespan of 17.9 days, while single mutant frh-1(RNAi) has a lifespan of 20.6 days, double mutant aak-1(tm1994);aak-2(ok524) has a lifespan of 14.6 days and wild type has a lifespan of 17.2 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-1 aak-2 frh-1 aak-1;aak-2;frh-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-1


Locus: CELE_PAR2.3


Wormbase description: aak-1 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); aak-1 activity is required, in parallel with aak-2 and downstream of daf-2, daf-7, and par-4, for negative regulation of germline proliferation during dauer development.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Frataxin, mitochondrial


Locus: CELE_F59G1.7


Wormbase description: frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.


Orthologs of aak-1;aak-2;frh-1 in SynergyAge
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Orthologs of aak-1 in SynergyAge
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Orthologs of aak-2 in SynergyAge
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Orthologs of frh-1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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