aak-2;rsks-1

Lifespan changes: From wild type to aak-2;rsks-1 / From aak-2;rsks-1 to multiple mutants

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Genetic mutants with aak-2, rsks-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Lifespan (days)

    9.7

  • Lifespan change (compared to wild type)

    -24.22%

  • Lifespan comparisons

    Double mutant aak-2(ok524);rsks-1(ok1255) has a lifespan of 9.7 days, while single mutant rsks-1(ok1255) has a lifespan of 14.7 days, single mutant aak-2(ok524) has a lifespan of 10.2 days and wild type has a lifespan of 12.8 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Lifespan (days)

    9.0

  • Lifespan change (compared to wild type)

    -30.77%

  • Lifespan comparisons

    Double mutant aak-2(ok524);rsks-1(ok1255) has a lifespan of 9.0 days, while single mutant rsks-1(ok1255) has a lifespan of 15.2 days, single mutant aak-2(ok524) has a lifespan of 11.3 days and wild type has a lifespan of 13.0 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    16.31

  • Lifespan change (compared to wild type)

    -20.90%

  • Phenotype

    The aak-2(ok524) null allele fully suppressed rsks-1 mutant longevity. This effect is likely to be specific since several other modes of C. elegans longevity are not aak-2 dependent.

  • Lifespan comparisons

    Double mutant aak-2(ok524);rsks-1(pk1255) has a lifespan of 16.31 days, while single mutant rsks-1(pk1255) has a lifespan of 23.09 days, single mutant aak-2(ok524) has a lifespan of 16.72 days and wild type has a lifespan of 20.62 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Selman C et al., 2009, Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science. 326(5949):140-4 PubMed 19797661 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    22.5

  • Diet

    NGM

  • Lifespan (days)

    17.9

  • Lifespan change (compared to wild type)

    1.13%

  • Phenotype

    The long lifespan of rsks-1(tm1714) mutants was suppressed by aak-2(ok524) mutation.

  • Lifespan comparisons

    Double mutant aak-2(ok524);rsks-1(tm1714) has a lifespan of 17.9 days, while single mutant aak-2(ok524) has a lifespan of 16.3 days, single mutant rsks-1(tm1714) has a lifespan of 22.0 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 PubMed 23879233 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    22.5

  • Diet

    NGM

  • Lifespan (days)

    12.8

  • Lifespan change (compared to wild type)

    -28.09%

  • Phenotype

    The long lifespan of rsks-1(tm1714) mutants was suppressed by aak-2(ok524) mutation.

  • Lifespan comparisons

    Double mutant aak-2(ok524);rsks-1(tm1714) has a lifespan of 12.8 days, while single mutant aak-2(ok524) has a lifespan of 14.5 days, single mutant rsks-1(tm1714) has a lifespan of 18.0 days and wild type has a lifespan of 17.8 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 PubMed 23879233 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 rsks-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Ribosomal protein S6 kinase beta


Locus: CELE_Y47D3A.16


Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).


Orthologs of aak-2;rsks-1 in SynergyAge
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Orthologs of aak-2 in SynergyAge
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Orthologs of rsks-1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
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