aakb-1;daf-2

Lifespan changes: From wild type to aakb-1;daf-2

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Genetic mutants with aakb-1, daf-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    25.5

  • Lifespan change (compared to wild type)

    78.32%

  • Phenotype

    aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively).

  • Lifespan comparisons

    Double mutant aakb-1(tm2658);daf-2(m577) has a lifespan of 25.5 days, while single mutant daf-2(m577) has a lifespan of 29.1 days, single mutant aakb-1(tm2658) has a lifespan of 12.6 days and wild type has a lifespan of 14.3 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    24.2

  • Lifespan change (compared to wild type)

    70.42%

  • Phenotype

    aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively).

  • Lifespan comparisons

    Double mutant aakb-1(tm2658);daf-2(m577) has a lifespan of 24.2 days, while single mutant daf-2(m577) has a lifespan of 31.2 days, single mutant aakb-1(tm2658) has a lifespan of 12.5 days and wild type has a lifespan of 14.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    27.2

  • Lifespan change (compared to wild type)

    101.48%

  • Phenotype

    aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively).

  • Lifespan comparisons

    Double mutant aakb-1(tm2658);daf-2(m577) has a lifespan of 27.2 days, while single mutant daf-2(m577) has a lifespan of 29.8 days, single mutant aakb-1(tm2658) has a lifespan of 13.1 days and wild type has a lifespan of 13.5 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    25.9

  • Lifespan change (compared to wild type)

    79.86%

  • Phenotype

    aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively).

  • Lifespan comparisons

    Double mutant aakb-1(tm2658);daf-2(m577) has a lifespan of 25.9 days, while single mutant daf-2(m577) has a lifespan of 28.7 days, single mutant aakb-1(tm2658) has a lifespan of 12.6 days and wild type has a lifespan of 14.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    25.2

  • Lifespan change (compared to wild type)

    66.89%

  • Phenotype

    aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively).

  • Lifespan comparisons

    Double mutant aakb-1(tm2658);daf-2(m577) has a lifespan of 25.2 days, while single mutant daf-2(m577) has a lifespan of 28.0 days, single mutant aakb-1(tm2658) has a lifespan of 12.5 days and wild type has a lifespan of 15.1 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakb-1 daf-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated Kinase Beta subunit


Locus: CELE_F55F3.1


Wormbase description: aakb-1 encodes one of two C. elegans AMP kinase (AMPK) beta regulatory subunits.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


Orthologs of aakb-1;daf-2 in SynergyAge
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Species Gene
Orthologs of aakb-1 in SynergyAge
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Species Gene
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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