aakg-4;aakg-5

Lifespan changes: From wild type to aakg-4;aakg-5 / From aakg-4;aakg-5 to multiple mutants

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Genetic mutants with aakg-4, aakg-5 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    12.2

  • Lifespan change (compared to wild type)

    25.77%

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);aakg-5(RNAi) has a lifespan of 12.2 days, while single mutant aakg-5(RNAi) has a lifespan of 10.7 days, single mutant aakg-4(tm5539) has a lifespan of 10.8 days and wild type has a lifespan of 9.7 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    10.6

  • Lifespan change (compared to wild type)

    7.07%

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);aakg-5(RNAi) has a lifespan of 10.6 days, while single mutant aakg-5(RNAi) has a lifespan of 10.0 days, single mutant aakg-4(tm5539) has a lifespan of 10.4 days and wild type has a lifespan of 9.9 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakg-4 aakg-5
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit


Locus: CELE_T01B6.3


Wormbase description: aakg-4 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit


Locus: CELE_R53.7


Wormbase description: aakg-5 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.


Orthologs of aakg-4;aakg-5 in SynergyAge
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Orthologs of aakg-4 in SynergyAge
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Species Gene
Orthologs of aakg-5 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group