aakg-4;daf-2

Lifespan changes: From wild type to aakg-4;daf-2 / From aakg-4;daf-2 to multiple mutants

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Genetic mutants with aakg-4, daf-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Lifespan (days)

    22.0

  • Lifespan change (compared to wild type)

    61.76%

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);daf-2(e1370) has a lifespan of 22.0 days, while single mutant daf-2(e1370) has a lifespan of 26.7 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 13.6 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Lifespan (days)

    21.4

  • Lifespan change (compared to wild type)

    67.19%

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);daf-2(e1370) has a lifespan of 21.4 days, while single mutant daf-2(e1370) has a lifespan of 28.8 days, single mutant aakg-4(RNAi) has a lifespan of 12.9 days and wild type has a lifespan of 12.8 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chen D et al., 2013, Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 5(6):1600-10 PubMed 24332851 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    19.7

  • Lifespan change (compared to wild type)

    103.09%

  • Phenotype

    Abrogated aakg-4 expression using RNAi, and observed a greater reduction in lifespan in daf-2 than in wild-type worms.

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);daf-2(m577) has a lifespan of 19.7 days, while single mutant aakg-4(RNAi) has a lifespan of 10.2 days, single mutant daf-2(m577) has a lifespan of 21.5 days and wild type has a lifespan of 9.7 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    20.0

  • Lifespan change (compared to wild type)

    102.02%

  • Phenotype

    Abrogated aakg-4 expression using RNAi, and observed a greater reduction in lifespan in daf-2 than in wild-type worms.

  • Lifespan comparisons

    Double mutant aakg-4(RNAi);daf-2(m577) has a lifespan of 20.0 days, while single mutant aakg-4(RNAi) has a lifespan of 9.9 days, single mutant daf-2(m577) has a lifespan of 23.8 days and wild type has a lifespan of 9.9 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    23.5

  • Lifespan change (compared to wild type)

    104.35%

  • Phenotype

    aakg-4 reduced lifespan in a daf-2(m577) background.

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 23.5 days, while single mutant aakg-4(tm5539) has a lifespan of 11.8 days, single mutant daf-2(m577) has a lifespan of 29.4 days and wild type has a lifespan of 11.5 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    23.9

  • Lifespan change (compared to wild type)

    115.32%

  • Phenotype

    aakg-4 reduced lifespan in a daf-2(m577) background.

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 23.9 days, while single mutant aakg-4(tm5539) has a lifespan of 11.2 days, single mutant daf-2(m577) has a lifespan of 29.5 days and wild type has a lifespan of 11.1 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    24.0

  • Lifespan change (compared to wild type)

    103.39%

  • Phenotype

    aakg-4 reduced lifespan in a daf-2(m577) background.

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 24.0 days, while single mutant aakg-4(tm5539) has a lifespan of 12.4 days, single mutant daf-2(m577) has a lifespan of 28.9 days and wild type has a lifespan of 11.8 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    23.7

  • Lifespan change (compared to wild type)

    102.56%

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 23.7 days, while single mutant daf-2(m577) has a lifespan of 29.9 days and wild type has a lifespan of 11.7 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    22.7

  • Lifespan change (compared to wild type)

    100.88%

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 22.7 days, while single mutant daf-2(m577) has a lifespan of 29.0 days and wild type has a lifespan of 11.3 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    18.2

  • Lifespan change (compared to wild type)

    83.84%

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 18.2 days, while single mutant aakg-4(tm5539) has a lifespan of 10.4 days, single mutant daf-2(m577) has a lifespan of 23.8 days and wild type has a lifespan of 9.9 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    18.9

  • Lifespan comparisons

    Double mutant aakg-4(tm5539);daf-2(m577) has a lifespan of 18.9 days, while single mutant daf-2(m577) has a lifespan of 24.1 days.

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakg-4 daf-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit


Locus: CELE_T01B6.3


Wormbase description: aakg-4 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


Orthologs of aakg-4;daf-2 in SynergyAge
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Species Gene
Orthologs of aakg-4 in SynergyAge
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Species Gene
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group