aak-2;xbp-1

Lifespan changes: From wild type to aak-2;xbp-1

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Genetic mutants with aak-2, xbp-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    16.0

  • Lifespan change (compared to wild type)

    -20.00%

  • Lifespan comparisons

    Double mutant aak-2(OE);xbp-1(RNAi) has a lifespan of 16.0 days, while single mutant xbp-1(RNAi) has a lifespan of 16.0 days, single mutant aak-2(OE) has a lifespan of 21.71 days and wild type has a lifespan of 20.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Hou L et al., 2016, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metab. 23(3):529-40 PubMed 26959186 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    16.75

  • Lifespan change (compared to wild type)

    -10.09%

  • Lifespan comparisons

    Double mutant aak-2(OE);xbp-1(RNAi) has a lifespan of 16.75 days, while single mutant xbp-1(RNAi) has a lifespan of 16.43 days, single mutant aak-2(OE) has a lifespan of 21.53 days and wild type has a lifespan of 18.63 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Hou L et al., 2016, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metab. 23(3):529-40 PubMed 26959186 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    28.29

  • Lifespan change (compared to wild type)

    41.45%

  • Lifespan comparisons

    Double mutant aak-2(OE);xbp-1(RNAi) has a lifespan of 28.29 days, while single mutant xbp-1(RNAi) has a lifespan of 17.23 days, single mutant aak-2(OE) has a lifespan of 23.19 days and wild type has a lifespan of 20.0 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Hou L et al., 2016, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metab. 23(3):529-40 PubMed 26959186 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 xbp-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

X-box Binding Protein homolog


Locus: CELE_R74.3


Wormbase description: xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); xbp-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development; loss of xbp-1 activity also results in near-complete loss of myo-2 pharnygeal myosin expression, although pharyngeal muscle is still present.


Orthologs of aak-2;xbp-1 in SynergyAge
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Orthologs of aak-2 in SynergyAge
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Orthologs of xbp-1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
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