aak-2;cyc-2.1

Lifespan changes: From wild type to aak-2;cyc-2.1

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Genetic mutants with aak-2, cyc-2.1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    15.9

  • Lifespan change (compared to wild type)

    -15.87%

  • Phenotype

    Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant.

  • Lifespan comparisons

    Double mutant aak-2(ok524);cyc-2.1(RNAi) has a lifespan of 15.9 days, while single mutant cyc-2.1(RNAi) has a lifespan of 32.2 days, single mutant aak-2(ok524) has a lifespan of 15.9 days and wild type has a lifespan of 18.9 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 PubMed 31340143 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    16.0

  • Lifespan change (compared to wild type)

    -20.00%

  • Phenotype

    Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant.

  • Lifespan comparisons

    Double mutant aak-2(ok524);cyc-2.1(RNAi) has a lifespan of 16.0 days, while single mutant cyc-2.1(RNAi) has a lifespan of 31.6 days, single mutant aak-2(ok524) has a lifespan of 16.0 days and wild type has a lifespan of 20.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 PubMed 31340143 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 cyc-2.1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Cytochrome c 2.1


Locus: CELE_E04A4.7


Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.


Orthologs of aak-2;cyc-2.1 in SynergyAge
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Orthologs of aak-2 in SynergyAge
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Orthologs of cyc-2.1 in SynergyAge
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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