Naam;Sirt1

Lifespan changes: From wild type to Naam;Sirt1 DF = decrease in function; IF = increase in function

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Genetic mutants with Naam, Sirt1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    D-NAAM[42];Sir2[4.5],[5.26]

  • Diet

    All of the fly stocks were maintained on standard cornmeal molasses medium. For the longevity experiments, the flies were mated and raised on sucrose medium.

  • Lifespan (days)

    36.88

  • Lifespan change (compared to wild type)

    -22.44%

  • Phenotype

    In adult females, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated.

  • Lifespan comparisons

    Double mutant Naam(if);Sirt1(df) has a lifespan of 36.88 days, while single mutant Sirt1(df) has a lifespan of 44.88 days, single mutant Naam(if) has a lifespan of 36.88 days and wild type has a lifespan of 47.55 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Balan V et al., 2008, Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem. 283(41):27810-9 PubMed 18678867 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    D-NAAM[42];Sir2[4.5],[5.26]

  • Diet

    All of the fly stocks were maintained on standard cornmeal molasses medium. For the longevity experiments, the flies were mated and raised on sucrose medium.

  • Lifespan (days)

    45.71

  • Phenotype

    In adult males, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated.

  • Lifespan comparisons

    Double mutant Naam(if);Sirt1(df) has a lifespan of 45.71 days, while single mutant Sirt1(df) has a lifespan of 47.61 days, single mutant Naam(if) has a lifespan of 57.14 days and wild type has a lifespan of 45.71 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Balan V et al., 2008, Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem. 283(41):27810-9 PubMed 18678867 Click here to select all mutants from this PubMed ID in the graph

Search genes: Naam Sirt1
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Nicotinamide amidase


Locus: Dmel_CG31216


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Sirtuin 1


Locus: Dmel_CG5216


Orthologs of Naam;Sirt1 in SynergyAge
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Orthologs of Naam in SynergyAge
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Orthologs of Sirt1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group