Mhc;Vinc

Lifespan changes: From wild type to Mhc;Vinc DF = decrease in function; IF = increase in function

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Genetic mutants with Mhc, Vinc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    UAS-MHC/tin-HE-Gal4;UAS-Vinculin/tin-HE-Gal4

  • Temperature °C

    25

  • Diet

    Standard agar-containing food.

  • Lifespan (days)

    35.0

  • Lifespan change (compared to wild type)

    19.05%

  • Phenotype

    Cardiac-specific vinculin overexpression substantially prolonged median organismal life span by as much as 150%. These data suggest that VincHE hearts produce greater contractile forces, that vinculin overexpression can rescue diminished force production, and that cardiac-specific vinculin overexpression can increase longevity.

  • Lifespan comparisons

    Double mutant Mhc(if);Vinc(if) has a lifespan of 35.0 days, while single mutant Vinc(if) has a lifespan of 75.6 days, single mutant Mhc(if) has a lifespan of 23.1 days and wild type has a lifespan of 29.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Kaushik G et al., 2015, Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med. 7(292):292ra99 PubMed 26084806 Click here to select all mutants from this PubMed ID in the graph

Search genes: Mhc Vinc
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Myosin heavy chain


Locus: Dmel_CG17927


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Vinculin


Locus: Dmel_CG3299


Orthologs of Mhc;Vinc in SynergyAge
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Species Gene
Orthologs of Mhc in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Vinc in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group