p38a;p38b

Lifespan changes: From wild type to p38a;p38b DF = decrease in function; IF = increase in function

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Genetic mutants with p38a, p38b alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    p38a[1];p38b[?45]

  • Temperature °C

    25

  • Diet

    Standard Drosophila culture medium

  • Lifespan (days)

    3.0

  • Lifespan change (compared to wild type)

    -93.88%

  • Phenotype

    A double mutant combination of the hypomorphic p38Kb?25 allele and p38Kadel (p38K-DKO) had a severely reduced lifespan. Single mutants of p38Ka (p38Kadel) or p38Kb (p38K?45) also had significantly reduced lifespan.

  • Lifespan comparisons

    Double mutant p38a(df);p38b(df) has a lifespan of 3.0 days, while single mutant p38b(df) has a lifespan of 19.0 days, single mutant p38a(df) has a lifespan of 34.0 days and wild type has a lifespan of 49.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Vrailas-Mortimer A et al., 2011, A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila. Dev Cell. 21(4):783-95 PubMed 22014527 Click here to select all mutants from this PubMed ID in the graph

Search genes: p38a p38b
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

p38a MAP kinase


Locus: Dmel_CG5475


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

p38b MAP kinase


Locus: Dmel_CG7393


Orthologs of p38a;p38b in SynergyAge
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Species Gene
Orthologs of p38a in SynergyAge
Show in SynergyAge
Species Gene
Caenorhabditis elegans pmk-1
Orthologs of p38b in SynergyAge
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Species Gene
Caenorhabditis elegans pmk-1
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

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