chico;foxo

Lifespan changes: From wild type to chico;foxo DF = decrease in function; IF = increase in function

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Genetic mutants with chico, foxo alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    chico[1];foxo[21]

  • Temperature °C

    25

  • Diet

    The feeding tube was a glass media vial with 3 ml standard diet (cornmeal (5.2%), sugar (11.0%), autolyzed yeast (2.5%; SAF brand) and agar (0.79%) (w/v in 100 mL water) with 0.2% Tegosep (methyl4-hydroxybenzoate, Sigma, St Louis, MO, USA), with additional live yeast sprinkled on the media surface) plugged into a silicone sleeve glued to the container wall.

  • Lifespan (days)

    42.0

  • Lifespan change (compared to wild type)

    -12.50%

  • Phenotype

    chico extends Drosophila longevity by acting through FOXO.

  • Lifespan comparisons

    Double mutant chico(df);foxo(df) has a lifespan of 42.0 days, while single mutant foxo(df) has a lifespan of 36.0 days, single mutant chico(df) has a lifespan of 70.0 days and wild type has a lifespan of 48.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Yamamoto R, Tatar M, 2011, Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan. Aging Cell. 10(4):729-32 PubMed 21518241 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    chico[1];foxo[21]

  • Temperature °C

    25

  • Diet

    The feeding tube was a glass media vial with 3 ml standard diet (cornmeal (5.2%), sugar (11.0%), autolyzed yeast (2.5%; SAF brand) and agar (0.79%) (w/v in 100 mL water) with 0.2% Tegosep (methyl4-hydroxybenzoate, Sigma, St Louis, MO, USA), with additional live yeast sprinkled on the media surface) plugged into a silicone sleeve glued to the container wall.

  • Lifespan (days)

    44.0

  • Phenotype

    chico extends Drosophila longevity by acting through FOXO.

  • Lifespan comparisons

    Double mutant chico(df);foxo(df) has a lifespan of 44.0 days, while single mutant foxo(df) has a lifespan of 36.0 days, single mutant chico(df) has a lifespan of 72.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Yamamoto R, Tatar M, 2011, Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan. Aging Cell. 10(4):729-32 PubMed 21518241 Click here to select all mutants from this PubMed ID in the graph

Search genes: chico foxo
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

chico


Locus: Dmel_CG5686


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

forkhead box, sub-group O


Locus: Dmel_CG3143


Orthologs of chico;foxo in SynergyAge
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Species Gene
Orthologs of chico in SynergyAge
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Species Gene
Orthologs of foxo in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group