Atm;Terc

Lifespan changes: From wild type to Atm;Terc

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Genetic mutants with Atm, Terc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    380.0

  • Lifespan change (compared to wild type)

    -37.70%

  • Phenotype

    Despite cancer resistance, the median lifespan of the G3/G4 Terc-/- Atm-/- mice was significantly shorter than that of G3/G4 Terc-/- Atm+/+ controls

  • Lifespan comparisons

    Double mutant Terc(KO);atm(KO) has a lifespan of 380.0 days, while single mutant atm(KO) has a lifespan of 395.0 days, single mutant Terc(KO) has a lifespan of 610.0 days and wild type has a lifespan of 610.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Wong KK et al., 2003, Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421(6923):643-8 PubMed 12540856 Click here to select all mutants from this PubMed ID in the graph

  • Lifespan (days)

    380.0

  • Lifespan change (compared to wild type)

    -37.70%

  • Phenotype

    Despite cancer resistance, the median lifespan of the G3/G4 Terc-/- Atm-/- mice was significantly shorter than that of G3/G4 Terc-/- Atm+/+ controls

  • Lifespan comparisons

    Double mutant atm(KO);Terc(KO) has a lifespan of 380.0 days, while single mutant atm(KO) has a lifespan of 395.0 days, single mutant Terc(KO) has a lifespan of 610.0 days and wild type has a lifespan of 610.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Wong KK et al., 2003, Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421(6923):643-8 PubMed 12540856 Click here to select all mutants from this PubMed ID in the graph

Search genes: Atm Terc
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

ataxia telangiectasia mutated


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

telomerase RNA component


Orthologs of Atm;Terc in SynergyAge
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Species Gene
Orthologs of Atm in SynergyAge
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Species Gene
Orthologs of Terc in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group