Shc1;Terc

Lifespan changes: From wild type to Shc1;Terc

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Genetic mutants with Shc1, Terc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    21

  • Diet

    2018S Teklad Global 18% Protein Rodent Diet

  • Lifespan (days)

    718.0

  • Lifespan change (compared to wild type)

    -12.44%

  • Lifespan comparisons

    Double mutant Terc(KO);p66SHC(KO) has a lifespan of 718.0 days, while single mutant Terc(KO) has a lifespan of 720.0 days and wild type has a lifespan of 820.0 days.

  • Type of interaction
    See methods

    Partially known monotony. Negative epistasis

  • Citation
    View abstract

    Giorgio M et al., 2016, P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. Aging Cell. 15(3):446-54 PubMed 26968134 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    2018S Teklad Global 18% Protein Rodent Diet

  • Lifespan (days)

    504.0

  • Lifespan change (compared to wild type)

    -38.54%

  • Lifespan comparisons

    Double mutant Terc(KO);p66SHC(KO) has a lifespan of 504.0 days, while wild type has a lifespan of 820.0 days.

  • Citation
    View abstract

    Giorgio M et al., 2016, P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. Aging Cell. 15(3):446-54 PubMed 26968134 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    2018S Teklad Global 18% Protein Rodent Diet

  • Lifespan (days)

    718.0

  • Lifespan change (compared to wild type)

    -12.44%

  • Lifespan comparisons

    Double mutant p66SHC(KO);Terc(KO) has a lifespan of 718.0 days, while single mutant Terc(KO) has a lifespan of 720.0 days and wild type has a lifespan of 820.0 days.

  • Type of interaction
    See methods

    Partially known monotony. Negative epistasis

  • Citation
    View abstract

    Giorgio M et al., 2016, P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. Aging Cell. 15(3):446-54 PubMed 26968134 Click here to select all mutants from this PubMed ID in the graph

Search genes: Shc1 Terc
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

src homology 2 domain-containing transforming protein C1


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

telomerase RNA component


Orthologs of Shc1;Terc in SynergyAge
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Species Gene
Orthologs of Shc1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Terc in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

Contact
Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group