aak-2;sod-1

Lifespan changes: From wild type to aak-2;sod-1

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Genetic mutants with aak-2, sod-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    18.8

  • Phenotype

    sod-1 OE robustly increased the life span of aak-2 mutants.

  • Lifespan comparisons

    Double mutant aak-2(ok524);sod-1(wuIs152) has a lifespan of 18.8 days, while single mutant sod-1(wuIs152) has a lifespan of 25.2 days and single mutant aak-2(ok524) has a lifespan of 15.9 days.

  • Citation
    View abstract

    Cabreiro F et al., 2011, Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med. 51(8):1575-82 PubMed 21839827 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    19.1

  • Lifespan comparisons

    Double mutant aak-2(ok524);sod-1(wuIs152) has a lifespan of 19.1 days, while single mutant aak-2(ok524) has a lifespan of 13.0 days.

  • Citation
    View abstract

    Cabreiro F et al., 2011, Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med. 51(8):1575-82 PubMed 21839827 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-2 sod-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-2


Locus: CELE_T01C8.1


Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_C15F1.7


Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).


Orthologs of aak-2;sod-1 in SynergyAge
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Species Gene
Orthologs of aak-2 in SynergyAge
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Species Gene
Orthologs of sod-1 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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