Fruit fly

Fruit fly

Drosophila melanogaster, one of the most studied insects.

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All mutants (27 results, without single mutants) Mutant type No. experiments Change in average lifespan   Epistasis
alpha-Man-Ia;Edem1 Double mutant 3 31.82% .. 40.91%  
ATPCL;chm Double mutant 1 -28.0% .. 83.67% [est.]
Cat;Sod1 Double mutant 24 -37.08% .. 29.03%  
chico;foxo Double mutant 2 -12.50% ..  
chico;ovo Double mutant 1 34.09%  
dhd;Trx-2 Double mutant 1 -4.10%  
E(z);trx Double mutant 2 5.41% .. 13.51%  
elav;Rbp9 Double mutant 1 -85.33% .. -62.59% [est.]
elav;Rbp9;Rbp9 Triple mutant 1 -86.67% .. -65.99% [est.]
foxo;InR Double mutant 2 -31.34% .. -13.11%  
foxo;Lrrk Double mutant 1 -8.24%  
foxo;Pi3K92E Double mutant 1 -32.00%  
foxo;rpr Double mutant 1 -26.67%  
HDAC1;Sirt1 Double mutant 2 -5.88%  
hep;puc Double mutant 1 -38.67% .. 56.46% [est.]
Lip2;rpr Double mutant 3 20.59% .. 60.00%  
Mhc;Vinc Double mutant 1 19.05%  
Naam;Sirt1 Double mutant 2 -22.44% ..  
Nf1;Nf1 Double mutant 2 -24.00% .. -22.73%  
Nf1;rut Double mutant 2 -56.82% .. -50.00%  
p38a;p38b Double mutant 1 -93.88%  
p38b;Sod2 Double mutant 1 12.24%  
Rbp9;Rbp9 Double mutant 1 -69.33% .. -21.77% [est.]
snz;snz Double mutant 2 86.54% .. 133.33%  
Sod1;Sod1 Double mutant 6 -98.0% .. -250.0% [est.]
sun;y Double mutant 2 24.00% .. 60.00%  
Trx-2;TrxT Double mutant 1 -7.68%  
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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