Mouse

Mouse

Mus musculus, one of the most important mammalian model organisms.

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All mutants (36 results, without single mutants) Mutant type No. experiments Change in average lifespan   Epistasis
Apc;Egr1 Double mutant 2 -83.24% .. -237.63% [est.]
Apc;Egr1;Trp53 Triple mutant 1 -83.24% .. -52.15% [est.]
Apc;Ku80 Double mutant 2 -73.60% .. -66.40%  
Apc;Trp53 Double mutant 1 -86.44% .. -61.29% [est.]
Atm;Rad54 Double mutant 1 -86.82% .. -62.37% [est.]
Atm;Rad54B Double mutant 1 -84.18% .. -54.84% [est.]
Atm;Sirt6 Double mutant 2 -87.1% .. -248.66% [est.]
Atm;Terc Double mutant 2 -37.70%  
bax;Ku70 Double mutant 6 -71.82% .. -60.00%  
Bub3;Rae1 Double mutant 1 -12.00%  
Cdkn1a;Terc Double mutant 1 -43.13% .. 62.37% [est.]
Cp;Heph Double mutant 1 -83.52% .. -52.96% [est.]
Cyp27b1;Fgf23 Double mutant 1 0.00%  
Dmd;mdx;Utrn Triple mutant 2 0.00%  
E2f1;Rb1 Double mutant 4 -66.85% .. -190.86% [est.]
Hgf;Sod1 Double mutant 1 -72.22% .. -20.7% [est.]
K-ras;Mdm4 Double mutant 2 -75.99% .. -216.94% [est.]
K-ras;Trp53 Double mutant 1 -69.07%  
Kl;Pai1 Double mutant 2 -84.65% .. -241.67% [est.]
Ku70;Ku80 Double mutant 1 -65.74%  
Ku80;Prkdc Double mutant 2 -78.31% .. -223.58% [est.]
Kv1.3;Mc4r Double mutant 1 -21.43%  
Mclk1;Trp53 Double mutant 1 -59.51% .. 15.59% [est.]
Mdm4;Trp53 Double mutant 5 -90.77% .. -259.14% [est.]
Mdx;Utrn Double mutant 2 -35.83%  
Mgat5;Pten Double mutant 4 -55.71% .. -33.33%  
Mobr;Sod1 Double mutant 1 -87.95% .. -65.59% [est.]
p18;Trp53 Double mutant 1 -84.65% .. -56.18% [est.]
p27;Trp53 Double mutant 1 -89.27% .. -69.35% [est.]
Pink1;Snca Double mutant 1 0.18%  
Prkdc;Terc Double mutant 1 -59.88%  
Rbm38;Trp53 Double mutant 2 -84.30% .. -42.15%  
Ripk3;Sod1 Double mutant 2 -83.99% .. -239.78% [est.]
Shc1;Terc Double mutant 3 -38.54% .. -12.44%  
Sirt6;Trp53 Double mutant 2 -76.32% .. -67.61%  
Terc;Trp53 Double mutant 1 -86.06% .. -60.22% [est.]
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

www.aging-research.group