Roundworm

Roundworm

Caenorhabditis elegans, the most popular nematode.

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All mutants (1770 results, without single mutants) Mutant type No. experiments Change in average lifespan   Epistasis
skn-1;trpa-1 Double mutant 1 -11.11%  
skn-1;vang-1 Double mutant 1 27.45%  
sod-1;sod-2 Double mutant 1 65.54%  
sod-1;sod-2;sod-3;sod-4;sod-5 5-mutant 1 15.41%  
sod-1;sod-2;sod-4 Triple mutant 1 31.64%  
sod-1;sod-3 Double mutant 1 18.64%  
sod-1;sod-3;sod-5 Triple mutant 1 6.78%  
sod-1;sod-4 Double mutant 1 -1.13%  
sod-1;sod-5 Double mutant 1 2.82%  
sod-1;xbp-1 Double mutant 2 11.68% .. 27.52%  
sod-2;sod-3 Double mutant 1 41.81%  
sod-2;sod-3;sod-5 Triple mutant 1 14.69%  
sod-2;sod-4 Double mutant 1 51.41%  
sod-2;sod-5 Double mutant 1 38.98%  
sod-3;sod-5 Double mutant 1 12.99%  
taf-4;tpk-1 Double mutant 1 -38.05% .. 151.29% [est.]
tcer-1;tcer-1 Double mutant 4 15.59% .. 32.97%  
trpa-1;unc-43 Double mutant 1 14.05%  
ubc-18;wwp-1 Double mutant 2 -3.76% .. 2.14%  
unc-31;unc-64 Double mutant 1 79.17%  
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group