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All mutants (1833 results, without single mutants) Organism Mutant type No. experiments Change in average lifespan Epistasis
aak-1;aak-2 Caenorhabditis elegans Double mutant 1 -15.12%  
aak-1;aak-2;frh-1 Caenorhabditis elegans Triple mutant 1 4.07%  
aak-1;frh-1 Caenorhabditis elegans Double mutant 1 25.00%  
aak-2;atp-3 Caenorhabditis elegans Double mutant 2 -40.12% .. -33.72%  
aak-2;cco-1 Caenorhabditis elegans Double mutant 2 40.70% .. 48.26%  
aak-2;chc-1 Caenorhabditis elegans Double mutant 1 -13.30%  
aak-2;cyc-2.1 Caenorhabditis elegans Double mutant 2 -20.00% .. -15.87%  
aak-2;daf-16 Caenorhabditis elegans Double mutant 2 -44.33% .. -27.00%  
aak-2;daf-16;daf-2 Caenorhabditis elegans Triple mutant 1 -35.37%  
aak-2;daf-2 Caenorhabditis elegans Double mutant 7 -14.00% .. 75.78%  
aak-2;daf-2;rsks-1 Caenorhabditis elegans Triple mutant 7 73.85% .. 175.89%  
aak-2;daf-9 Caenorhabditis elegans Double mutant 1 10.81%  
aak-2;fasn-1 Caenorhabditis elegans Double mutant 1 -11.82%  
aak-2;frh-1 Caenorhabditis elegans Double mutant 2 -5.23% .. 34.30%  
aak-2;ifg-1 Caenorhabditis elegans Double mutant 1 7.88%  
aak-2;igf-1 Caenorhabditis elegans Double mutant 1 -12.18%  
aak-2;isp-1 Caenorhabditis elegans Double mutant 2 31.98% .. 125.58%  
aak-2;let-711 Caenorhabditis elegans Double mutant 1 -14.78%  
aak-2;mdt-15 Caenorhabditis elegans Double mutant 1 -39.90%  
aak-2;nmur-1 Caenorhabditis elegans Double mutant 1 23.21%  
aak-2;nuo-2 Caenorhabditis elegans Double mutant 2 22.09% .. 30.23%  
aak-2;rsks-1 Caenorhabditis elegans Double mutant 5 -30.77% .. 1.13%  
aak-2;sca-1 Caenorhabditis elegans Double mutant 1 -10.84%  
aak-2;sod-1 Caenorhabditis elegans Double mutant 2 -45.48% .. -184.47% [est.]
aak-2;unc-70 Caenorhabditis elegans Double mutant 1 -14.78%  
aak-2;xbp-1 Caenorhabditis elegans Double mutant 3 -20.00% .. 41.45%  
aakb-1;daf-2 Caenorhabditis elegans Double mutant 5 66.89% .. 101.48%  
aakg-1;daf-2;rff-3 Caenorhabditis elegans Triple mutant 4 -32.13% .. -130.35% [est.]
aakg-2;daf-2;rff-3 Caenorhabditis elegans Triple mutant 4 -24.88% .. -100.94% [est.]
aakg-3;daf-2;rff-3 Caenorhabditis elegans Triple mutant 4 -28.07% .. -113.88% [est.]
aakg-4;aakg-5 Caenorhabditis elegans Double mutant 2 7.07% .. 25.77%  
aakg-4;aakg-5;daf-2 Caenorhabditis elegans Triple mutant 2 98.99%  
aakg-4;daf-2 Caenorhabditis elegans Double mutant 11 61.76% .. 115.32%  
aakg-4;daf-2;rff-3 Caenorhabditis elegans Triple mutant 6 -42.0% .. -170.35% [est.]
aakg-4;daf-2;rsks-1 Caenorhabditis elegans Triple mutant 2 90.63% .. 91.18%  
aakg-4;rrf-3 Caenorhabditis elegans Double mutant 4 -70.13% .. -284.47% [est.]
aakg-4;rsks-1 Caenorhabditis elegans Double mutant 2 3.12% .. 10.29%  
aakg-5;daf-2 Caenorhabditis elegans Double mutant 3 74.23% .. 104.04%  
aakg-5;daf-2;rff-3 Caenorhabditis elegans Triple mutant 5 -48.38% .. -196.24% [est.]
aakg-5;rrf-3 Caenorhabditis elegans Double mutant 1 -65.2% .. 41.18% [est.]
aap-1;asm-3 Caenorhabditis elegans Double mutant 1 48.87% .. 503.88% [est.]
aat-2;daf-16;rrf-3 Caenorhabditis elegans Triple mutant 1 -23.27%  
abu-11;daf-2 Caenorhabditis elegans Double mutant 4 40.20% .. 123.04%  
acdh-13;daf-16;rrf-3 Caenorhabditis elegans Triple mutant 1 12.19%  
aco-2;daf-2 Caenorhabditis elegans Double mutant 2 35.06% .. 142.24% [est.]
acs-5;daf-16;rrf-3 Caenorhabditis elegans Triple mutant 1 -13.73%  
ada-2;daf-16;daf-2 Caenorhabditis elegans Triple mutant 1 -41.50%  
ada-2;daf-2 Caenorhabditis elegans Double mutant 1 95.92%  
age-1;akt-1;sqt-1 Caenorhabditis elegans Triple mutant 1 83.33%  
age-1;asm-3 Caenorhabditis elegans Double mutant 1 258.76%  
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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