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All mutants (1833 results, without single mutants) Organism Mutant type No. experiments Change in average lifespan Epistasis
age-1;cst-1 Caenorhabditis elegans Double mutant 1 29.45%  
age-1;cup-4 Caenorhabditis elegans Double mutant 2 6.43% .. 20.81%  
age-1;daf-16 Caenorhabditis elegans Double mutant 2 -31.08% .. -22.84%  
age-1;daf-16;drp1 Caenorhabditis elegans Triple mutant 1 -33.06%  
age-1;daf-16;fer-15 Caenorhabditis elegans Triple mutant 1 8.33%  
age-1;daf-16;sqt-1 Caenorhabditis elegans Triple mutant 1 16.67%  
age-1;daf-18;fer-15 Caenorhabditis elegans Triple mutant 1 0.00%  
age-1;daf-2;fer-15 Caenorhabditis elegans Triple mutant 2 96.00% .. 107.14%  
age-1;drp-1 Caenorhabditis elegans Double mutant 3 111.97% .. 149.24%  
age-1;fer-15 Caenorhabditis elegans Double mutant 5 24.00% .. 125.00%  
age-1;fer-15;gro-1 Caenorhabditis elegans Triple mutant 1 128.86%  
age-1;hcf-1 Caenorhabditis elegans Double mutant 2 82.76% .. 99.25%  
age-1;hsf-1 Caenorhabditis elegans Double mutant 2 -20.26% .. -9.63%  
age-1;ife-2 Caenorhabditis elegans Double mutant 1 51.10%  
age-1;nlp-7 Caenorhabditis elegans Double mutant 2 9.94% .. 15.61%  
age-1;oga-1 Caenorhabditis elegans Double mutant 1 55.35%  
age-1;ogt-1 Caenorhabditis elegans Double mutant 1 0.00%  
age-1;sgk-1 Caenorhabditis elegans Double mutant 1 104.08%  
age-1;shc-1 Caenorhabditis elegans Double mutant 1 23.24%  
age-1;skn-1 Caenorhabditis elegans Double mutant 1 14.45%  
age-1;sqt-1 Caenorhabditis elegans Double mutant 1 50.00%  
aha-1;clk-1 Caenorhabditis elegans Double mutant 1 0.00%  
aha-1;isp-1 Caenorhabditis elegans Double mutant 2 13.92%  
aha-1;mekk-3 Caenorhabditis elegans Double mutant 2 -26.26% .. -24.07%  
aha-1;tpk-1 Caenorhabditis elegans Double mutant 1 -16.3% .. 239.53% [est.]
ahr-1;mekk-3 Caenorhabditis elegans Double mutant 4 -14.65% .. 19.91%  
ain-1;daf-16;daf-2 Caenorhabditis elegans Triple mutant 1 -40.14%  
ain-1;daf-2 Caenorhabditis elegans Double mutant 1 111.56%  
akt-1;akt-2 Caenorhabditis elegans Double mutant 5 19.05% .. 220.67%  
akt-1;akt-2;ets-4 Caenorhabditis elegans Triple mutant 1 -28.65% .. 189.41% [est.]
akt-1;akt-2;jnk-1 Caenorhabditis elegans Triple mutant 1 160.40%  
akt-1;akt-2;rrf-3 Caenorhabditis elegans Triple mutant 1 63.04%  
akt-1;akt-2;rrf-3;skn-1 Caenorhabditis elegans 4-mutant 3 -15.94% .. 47.83%  
akt-1;akt-2;sgk-1 Caenorhabditis elegans Triple mutant 1 54.42%  
akt-1;asm-3 Caenorhabditis elegans Double mutant 1 -5.73%  
akt-1;daf-16 Caenorhabditis elegans Double mutant 2 -39.04% .. -34.78%  
akt-1;eak-3 Caenorhabditis elegans Double mutant 2 0.64% .. 2.36%  
akt-1;eak-4 Caenorhabditis elegans Double mutant 2 1.92% .. 3.15%  
akt-1;eak-6 Caenorhabditis elegans Double mutant 2 0.79% .. 1.92%  
akt-1;eak-7 Caenorhabditis elegans Double mutant 2 80.85% .. 92.52%  
akt-1;rict-1 Caenorhabditis elegans Double mutant 2 61.71% .. 69.78%  
akt-1;sdf-9 Caenorhabditis elegans Double mutant 4 15.38%  
akt-1;sgk-1 Caenorhabditis elegans Double mutant 3 -25.17% .. 20.69%  
akt-1;trpa-1 Caenorhabditis elegans Double mutant 1 35.53%  
akt-1;utx-1 Caenorhabditis elegans Double mutant 3 62.28% .. 86.76%  
akt-2;eak-7 Caenorhabditis elegans Double mutant 2 62.00% .. 74.83%  
akt-2;trpa-1 Caenorhabditis elegans Double mutant 1 58.31%  
akt-2;utx-1 Caenorhabditis elegans Double mutant 2 11.64% .. 34.72%  
alg-2;daf-16;daf-2 Caenorhabditis elegans Triple mutant 1 -32.65%  
alg-2;daf-2 Caenorhabditis elegans Double mutant 1 29.25%  
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

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