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All mutants (1833 results, without single mutants) Organism Mutant type No. experiments Change in average lifespan Epistasis
sgk-1;trpa-1 Caenorhabditis elegans Double mutant 3 -19.39% .. 22.97%  
sgk-1;utx-1 Caenorhabditis elegans Double mutant 2 26.33% .. 31.75%  
Shc1;Terc Mus musculus Double mutant 3 -38.54% .. -12.44%  
sir-2.1;unc-13 Caenorhabditis elegans Double mutant 2 53.41% .. 71.02%  
sir-2.1;unc-51 Caenorhabditis elegans Double mutant 2 -25.17% .. -102.12% [est.]
sir-2.1;unc-64 Caenorhabditis elegans Double mutant 1 147.53%  
sir-2.1;utx-1 Caenorhabditis elegans Double mutant 2 46.17% .. 52.97%  
Sirt6;Trp53 Mus musculus Double mutant 2 -76.32% .. -67.61%  
skn-1;trpa-1 Caenorhabditis elegans Double mutant 1 -11.11%  
skn-1;vang-1 Caenorhabditis elegans Double mutant 1 27.45%  
snz;snz Drosophila melanogaster Double mutant 2 86.54% .. 133.33%  
sod-1;sod-2 Caenorhabditis elegans Double mutant 1 65.54%  
sod-1;sod-2;sod-3;sod-4;sod-5 Caenorhabditis elegans 5-mutant 1 15.41%  
sod-1;sod-2;sod-4 Caenorhabditis elegans Triple mutant 1 31.64%  
sod-1;sod-3 Caenorhabditis elegans Double mutant 1 18.64%  
sod-1;sod-3;sod-5 Caenorhabditis elegans Triple mutant 1 6.78%  
sod-1;sod-4 Caenorhabditis elegans Double mutant 1 -1.13%  
sod-1;sod-5 Caenorhabditis elegans Double mutant 1 2.82%  
sod-1;xbp-1 Caenorhabditis elegans Double mutant 2 11.68% .. 27.52%  
sod-2;sod-3 Caenorhabditis elegans Double mutant 1 41.81%  
sod-2;sod-3;sod-5 Caenorhabditis elegans Triple mutant 1 14.69%  
sod-2;sod-4 Caenorhabditis elegans Double mutant 1 51.41%  
sod-2;sod-5 Caenorhabditis elegans Double mutant 1 38.98%  
sod-3;sod-5 Caenorhabditis elegans Double mutant 1 12.99%  
Sod1;Sod1 Drosophila melanogaster Double mutant 6 -98.0% .. -250.0% [est.]
sun;y Drosophila melanogaster Double mutant 2 24.00% .. 60.00%  
taf-4;tpk-1 Caenorhabditis elegans Double mutant 1 -38.05% .. 151.29% [est.]
tcer-1;tcer-1 Caenorhabditis elegans Double mutant 4 15.59% .. 32.97%  
Terc;Trp53 Mus musculus Double mutant 1 -86.06% .. -60.22% [est.]
trpa-1;unc-43 Caenorhabditis elegans Double mutant 1 14.05%  
Trx-2;TrxT Drosophila melanogaster Double mutant 1 -7.68%  
ubc-18;wwp-1 Caenorhabditis elegans Double mutant 2 -3.76% .. 2.14%  
unc-31;unc-64 Caenorhabditis elegans Double mutant 1 79.17%  
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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Computational Biology of Aging Group
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

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