Roundworm

Roundworm

Caenorhabditis elegans, the most popular nematode.

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All mutants (1770 results, without single mutants) Mutant type No. experiments Change in average lifespan   Epistasis
amt-2;daf-16;rrf-3 Triple mutant 1 -6.73%  
arx-4;daf-16;daf-2 Triple mutant 1 -66.67%  
arx-4;daf-2 Double mutant 1 -6.12%  
asb-2;daf-16 Double mutant 1 -38.52% .. 149.41% [est.]
asb-2;daf-2 Double mutant 1 69.95% .. 589.41% [est.]
asb-2;fem-1;fer-15 Triple mutant 1 -44.61% .. 124.71% [est.]
ash-2;rrf-1 Double mutant 3 28.22% .. 39.73%  
asm-1;asm-3;rrf-3 Triple mutant 1 30.46%  
asm-1;daf-18;rrf-3 Triple mutant 1 -71.0% .. 17.65% [est.]
asm-2;asm-3;rrf-3 Triple mutant 1 28.16%  
asm-2;daf-18;rrf-3 Triple mutant 1 -69.84% .. 22.35% [est.]
asm-3;daf-16 Double mutant 1 -7.43%  
asm-3;daf-16;rrf-3 Triple mutant 2 -26.44% .. -11.76%  
asm-3;daf-18;rrf-3 Triple mutant 1 -70.71% .. 18.82% [est.]
asm-3;daf-2 Double mutant 1 147.53%  
asm-3;pdk-1 Double mutant 1 50.69%  
asm-3;rrf-3 Double mutant 1 15.52%  
asp-3;daf-2;fem-23;fer-15 4-mutant 1 -24.59% .. 205.88% [est.]
asp-3;fem-1;fer-15 Triple mutant 1 -56.5% .. 76.47% [est.]
atf-6;daf-2 Double mutant 3 47.06% .. 115.66%  
atfs-1;cco-1 Double mutant 1 57.15%  
atfs-1;cyc-2.1 Double mutant 2 1.50% .. 4.76%  
atfs-1;daf-2;rsks-1 Triple mutant 3 99.49% .. 123.86%  
atg-10;daf-2 Double mutant 2 79.91% .. 86.45%  
atg-16.2;daf-2 Double mutant 2 88.13% .. 104.21%  
atg-18;daf-2 Double mutant 2 11.21% .. 77.63%  
atg-18;glp-1 Double mutant 3 -21.86% .. -8.06%  
atg-18;mes-1 Double mutant 1 -26.51%  
atg-18;rsks-1 Double mutant 4 -4.62% .. 3.90%  
atg-3;daf-2 Double mutant 2 87.67% .. 105.14%  
atg-4.1;daf-2 Double mutant 2 69.41% .. 74.30%  
atg-4.2;daf-2 Double mutant 2 73.36% .. 81.28%  
atg-5;daf-2 Double mutant 2 84.02% .. 119.63%  
atg-7;daf-2 Double mutant 2 68.95% .. 95.79%  
atg-9;ced-3 Double mutant 1 -25.46% .. 202.35% [est.]
atg-9;clk-1 Double mutant 1 -20.82% .. 221.18% [est.]
atg-9;daf-16 Double mutant 1 -60.56% .. 60.0% [est.]
atg-9;daf-16;sir-2.1 Triple mutant 1 -61.14% .. 57.65% [est.]
atg-9;daf-2 Double mutant 2 110.28% .. 113.24%  
atg-9;mev-1 Double mutant 1 -51.57% .. 96.47% [est.]
atg-9;rsks-1 Double mutant 1 -36.19% .. 158.82% [est.]
atg-9;sir-2.1 Double mutant 2 -19.37% .. -78.59% [est.]
atk-1;oga-1 Double mutant 1 24.53%  
atm-1;atp-3 Double mutant 2 -75.00% .. -68.71%  
atm-1;frh-1 Double mutant 2 54.02% .. 60.74%  
atp-3;cep-1 Double mutant 2 -27.65% .. 61.64%  
atp-3;daf-16 Double mutant 1 -57.95% .. 70.59% [est.]
atp-3;daf-2 Double mutant 1 18.33% .. 380.0% [est.]
atp-3;egl-1 Double mutant 1 -52.76%  
atp-3;fem-1;fer-15 Triple mutant 1 -26.91% .. 196.47% [est.]
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group